IELTS READING – The Search for the Anti-aging Pill S35AT3

| IELTS Reading The Search for the Anti-aging Pill reading practice test has 10 questions belongs to đ§Ź Health & Medicine subject.. |
In government laboratories and elsewhere, scientists are seeking a drug able to prolong life and youthful vigor. Studies of caloric restriction are showing the way

Q28 As researchers on aging noted recently, no treatment on the market today has been proved to slow human aging – the build-up of molecular and cellular damage that increases vulnerability to infirmity as we grow older. Q29 But one intervention, consumption of a low-calorie* yet nutritionally balanced diet, works incredibly well in a broad range of animals, increasing longevity and prolonging good health. Those findings suggest that caloric restriction could delay aging and increase longevity in humans, too.
Unfortunately, for maximum benefit, people would probably have to reduce their caloric intake by roughly thirty percent, equivalent to dropping from 2,500 calories a day to 1,750. Q30 Few mortals could stick to that harsh a regimen, especially for years on end. But what if someone could create a pill that mimicked the physiological effects of eating less without actually forcing people to eat less? Could such a âcaloric restriction mimeticâ, as we call it, enable people to stay healthy longer, postponing age-related disorders (such as diabetes, arteriosclerosis, heart disease, and cancer) until very late in life? Scientists first posed this question in the mid-1990s, after researchers came upon a chemical agent that in rodents seemed to reproduce many of caloric restrictionâs benefits. No compound that would safely achieve the same feat in people has been found yet, but the search has been informative and has fanned hope that caloric restriction (CR) mimetics can indeed be developed eventually.
The benefits of caloric restriction
The hunt for CR mimetics grew out of a desire to better understand caloric restrictionâs many effects on the body. Scientists first recognized the value of the practice more than 60 years ago, when Q32 they found that rats fed a low-calorie diet lived longer on average than free-feeding rats and also had a reduced incidence of conditions that become increasingly common in old age. What is more, some of the treated animals survived longer than the oldest-living animals in the control group, which means that the maximum lifespan (the oldest attainable age), not merely the normal lifespan, increased. Various interventions, such as infection-fighting drugs, can increase a populationâs average survival time, but only approaches that slow the bodyâs rate of aging will increase the maximum lifespan.
The rat findings have been replicated many times and extended to creatures ranging from yeast to fruit flies, worms, fish, spiders, mice, and hamsters. Until fairly recently, the studies were limited to short-lived creatures genetically distant from humans. But caloric-restriction projects underway in two species more closely related to humans – rhesus and squirrel monkeys – have made scientists optimistic that CR mimetics could help people.

The monkey projects demonstrate that, compared with control animals that eat normally, Q37 caloric-restricted monkeys have lower body temperatures and levels of the pancreatic hormone insulin, and they retain more youthful levels of certain hormones that tend to fall with age.
Q33&36 The caloric-restricted animals also look better on indicators of risk for age-related diseases. For example, they have lower blood pressure and triglyceride levels (signifying a decreased likelihood of heart disease), and they have more normal blood glucose levels (pointing to a reduced risk for diabetes, which is marked by unusually high blood glucose levels). Further, Q34 it has recently been shown that rhesus monkeys kept on caloric-restricted diets for an extended time (nearly 15 years) have less chronic disease. Q35 They and the other monkeys must be followed still longer, however, to know whether low-calorie intake can increase both average and maximum lifespans in monkeys. Unlike the multitude of elixirs being touted as the latest anti-aging cure, CR mimetics would alter fundamental processes that underlie aging. We aim to develop compounds that fool cells into activating maintenance and repair.


How a prototype caloric-restriction mimetic works
The best-studied candidate for a caloric-restriction mimetic, 2DG (2-deoxy-D-glucose), works by interfering with the way cells process glucose. It has proved toxic at some doses in animals and so cannot be used in humans. But it has demonstrated that chemicals can replicate the effects of caloric restriction; the trick is finding the right one.
Cells use the glucose from food to generate ATP (adenosine triphosphate), the molecule that powers many activities in the body. By limiting food intake, caloric restriction minimizes the amount of Q38 glucose entering cells and decreases ATP generation. When 2DG is administered to animals that eat normally, glucose reaches cells in abundance but the drug prevents most of it from being processed and thus reduces ATP synthesis. Researchers have proposed several explanations for why interruption of glucose processing and ATP production might retard aging. One possibility relates to the ATP-making machineryâs emission of Q39 free radicals, which are thought to contribute to aging and to such age-related diseases as cancer by damaging cells. Reduced operation of the machinery should limit their production and thereby constrain the damage. Another hypothesis suggests that decreased processing of glucose could indicate to cells that food is scarce (even if it isnât) and induce them to shift into an anti-aging mode that emphasizes Q40 preservation of the organism over such âluxuriesâ as growth and reproduction.
Learn From Experienced Teacher Best IELTS Coaching Dehradun Best IELTS in Dehradun Uttarakhand GMS Road BEST coaching in Dehradun Apply for Class Courses Today Good Results.
![]()
8439000086
8439000087
7055710003
7055710004
IELTS Simulation 323 GMS Road, Near Ballupur Chowk, Dehradun, India
email: info at ieltsband7.com
Boost Your Score: Practice IELTS Online with IELTS Simulator Prepare for IELTS Effectively Using IELTS Simulator Ace the IELTS: Try Realistic Practice on IELTS Simulator IELTS Simulator: Online Practice to Improve Your IELTS Score Rocky Bay field trip listening practice test has 10 questions belongs to the Leisure & Entertainment subject. Prepare for IELTS IELTS Test International Experienced Teacher Best Training By CELTA Trainer. Best Results Easily Get Required Score IELTS Exam Dates Available, Small Batch Size with Flexible Time, Professional. Easily Get Required Score I am interested in IELTS Pass with Confidence, Dehradun Small Batch Size with Flexible Time, professional faculty. Learn From Experienced Teacher Best IELTS Coaching Dehradun Best IELTS in Dehradun Uttarakhand GMS Road BEST coaching in Dehradun Apply for Class Courses Today Good Results. Small Batch Size, Flexible Time and Professional IELTS Teacher Best IELTS coaching classes IDP certified British Council trained and CELTA certified experienced trainer. Easily Get Required Score Tel:8439000086 Tel:8439000087 Tel:7055710003 Tel:7055710004 Tel:7055710009











